Utility of Bromelain and N-Acetylcysteine in Treatment of Peritoneal Dissemination of Gastrointestinal Mucin-Producing Malignancies

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Doctor’s Best Nattokinase – 2, 000 FU of Enzyme – this formulation is NSK-SD with no vitamin K2. Vitamin K2 counters the effect of warfarin. NAC might disrupt blood clotting and lower blood pressure. Taking NAC with nitroglycerine or isosorbide (used to treat chest pain) might cause low blood pressure and severe headaches.[4] Lepri E, Gambelunghe C, Fioravanti A, Pedini M, Micheletti A, Rufini S: N-acetylcysteine increases apoptosis induced by H(2) O(2) and mo-antiFas triggering in a 3DO hybridoma cell line. Cell Biochem Funct. 2000, 18: 201-208. 10.1002/1099-0844(200009)18:3<201::AID-CBF873>3.0.CO;2-A.

To evaluate the efficacy of an association of N-acetyl cystein, alpha-lipoic acid, and bromelain (NAC/LA/Br) in the treatment of endometriosis we set up a new in vivo murine model. We explored the anti-inflammatory and proapoptotic effect of this combination on human endometriotic endothelial cells (EECs) and on endothelial cells isolated from normal uterus (UtMECs). We implanted fragments of human endometriotic cysts intraperitoneally into SCID mice to evaluate the efficacy of NAC/LA/Br treatment. UtMECs and EECs, untreated or treated with NAC/LA/Br, were activated with the proinflammatory stimulus TNF-α and their response in terms of VCAM1 expression was evaluated. The proapoptotic effect of higher doses of NAC/LA/Br on UtMECs and EECs was measured with a fluorogenic substrate for activated caspases 3 and 7. The preincubation of EECs with NAC/LA/Br prior to cell stimulation with TNF-α prevents the upregulation of the expression of the inflammatory "marker" VCAM1. Furthermore NAC/LA/Br were able to induce EEC, but not UtMEC, apoptosis. Finally, the novel mouse model allowed us to demonstrate that mice treated with NAC/LA/Br presented a lower number of cysts, smaller in size, compared to untreated mice. Our findings suggest that these dietary supplements may have potential therapeutic uses in the treatment of chronic inflammatory diseases like endometriosis.Sceneay J, Liu MC, Chen A, Wong CS, Bowtell DD, Moller A: The antioxidant N-acetylcysteine prevents HIF-1 stabilization under hypoxia in vitro but does not affect tumorigenesis in multiple breast cancer models in vivo . PLoS One 2013, 8:e66388.,

ANTI-CANCER– exact mechanism unknown, theorized to inhibit tumor cell proliferation & metastasis, triggers apoptosis and triggers AUTOPHAGY. Also upregulates p53. Shown to be effective against breast cancer, melanoma, leukemias & lymphomas, GI, Colon, pancreatic and liver cancers.Cai Y., Zhang J., Xiao T., Peng H., Sterling S.M., Walsh R.M., Jr., Rawson S., Rits-Volloch S., Chen B. Distinct conformational states of SARS-CoV-2 spike protein. Science. 2020;369:1586–1592. doi: 10.1126/science.abd4251. Song Y., Zhang M., Yin L., Wang K., Zhou Y., Zhou M., Lu Y. COVID-19 treatment: Close to a cure?–a rapid review of pharmacotherapies for the novel coronavirus. Int. J. Antimicrob. Agents. 2020;56:106080. doi: 10.1016/j.ijantimicag.2020.106080. Research suggests that some people may experience allergic reactions when using Bromelain. People who are allergic to pineapple are particularly vulnerable. My Take…